We all have friends who communicate primarily through pop culture references and quotations. I can very easily lapse into this behavior myself. I s'pose this could be viewed as a distancing mechanism, a substitute for real expression, but I prefer to see it as employing a common language. There are just some situations, in certain company, where the most meaningful thing you can say is "you using the whole fist, doc?", or "I wonder who owns that moon?".
Which is to say: your mileage may vary, but I for one got a little choked up reading this webcomic.